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Phenotypes Associated with This Genotype
Genotype
MGI:5474681
Allelic
Composition		 Gabrg2tm2Spet/Gabrg2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
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Mouse lines carrying:
Gabrg2tm2Spet mutation (0 available); any Gabrg2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased susceptibility to pharmacologically induced seizures ( J:194196 )
• induced by pentylenetetrazil compared with Gabrg2tm2Spet/Gabrg2+ Tg(Camk2a-tTA)1Mmay Tg(tetO-cre)LC1Bjd mice (no doxycycline treatment)
• however, no seizure kindling effect is observed

nervous system
decreased susceptibility to pharmacologically induced seizures ( J:194196 )
• induced by pentylenetetrazil compared with Gabrg2tm2Spet/Gabrg2+ Tg(Camk2a-tTA)1Mmay Tg(tetO-cre)LC1Bjd mice (no doxycycline treatment)
• however, no seizure kindling effect is observed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory