Phenotypes Associated with This Genotype

Genotype
MGI:5475148

• Allelic Composition: Scmh1^tm1Yota/Scmh1^tm1Yota
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:194424 )

N • mice are fertile

hematopoietic system

myeloid hyperplasia ( J:194424 )

• in the bone marrow

decreased B cell number ( J:194424 )

• in the bone marrow

decreased T cell number ( J:194424 )

• decreased CD3+ cells in the bone marrow

abnormal hematopoietic stem cell morphology ( J:194424 )

• increased hematopoietic stem cells, multipotent progenitor cells and hematopoietic progenitor cells in the bone marrow

increased hematopoietic stem cell number ( J:194424 )

• in the bone marrow

abnormal fetal liver hematopoietic progenitor cell morphology ( J:194424 )

• increased clonogenic and long-term-culture-initiating cell activities

skeleton

skeleton phenotype ( J:194424 )

N • mice exhibit normal skeleton morphology

immune system

myeloid hyperplasia ( J:194424 )

• in the bone marrow

decreased B cell number ( J:194424 )

• in the bone marrow

decreased T cell number ( J:194424 )

• decreased CD3+ cells in the bone marrow