Phenotypes Associated with This Genotype

Genotype
MGI:5475165

• Allelic Composition: Nhej1^tm1.1Ics/Nhej1^tm1.1Ics
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased thymocyte apoptosis ( J:194422 )

abnormal T cell receptor V(D)J recombination ( J:194422 )

• 2-fold reduction in recombination activity in double negative thymocytes

• the frequency of distal Valpha segment is reduced while the usage of proximal segments is increased 3.2-fold

• usage of distal Valpha segments is reduced in the thymus and spleen

• usage of 5' Jalpha segments is increased

decreased lymphocyte cell number ( J:194422 )

• slightly in the thymus, spleen and lymph nodes

decreased thymocyte number ( J:194422 )

decreased NK T cell number ( J:194422 )

• invariant NK T cells

cellular

increased sensitivity to induced cell death ( J:194422 )

• in mouse embryonic fibroblasts treated with phleomycin

increased thymocyte apoptosis ( J:194422 )

hematopoietic system

increased thymocyte apoptosis ( J:194422 )

abnormal T cell receptor V(D)J recombination ( J:194422 )

• 2-fold reduction in recombination activity in double negative thymocytes

• the frequency of distal Valpha segment is reduced while the usage of proximal segments is increased 3.2-fold

• usage of distal Valpha segments is reduced in the thymus and spleen

• usage of 5' Jalpha segments is increased

decreased lymphocyte cell number ( J:194422 )

• slightly in the thymus, spleen and lymph nodes

decreased thymocyte number ( J:194422 )

decreased NK T cell number ( J:194422 )

• invariant NK T cells

endocrine/exocrine glands

increased thymocyte apoptosis ( J:194422 )

decreased thymocyte number ( J:194422 )