Analysis Tools
reproductive system
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• block of differentiation of Aal spermatogonia into A1 spermatogonia at 2 and 3 weeks of age
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• most tubules are devoid of meiotic cells at 2 and 3 weeks of age, retaining only undifferentiated spermatogonia-like cells and Sertoli cells
• however, by 9 weeks of age, tubules contain the expected spermatogonia,
spermatocytes, and spermatids
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• over 85% of tubules are degenerated at 2 and 3 weeks of age
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small testis
(
J:193281
)
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• at 2 and 3 weeks of age
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• dramatically lower at 2 and 3 weeks of age compared to wild-type controls and homozygous mice carrying only one of the cre transgenes
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• most tubules are devoid of meiotic cells at 2 and 3 weeks of age, retaining only undifferentiated spermatogonia-like cells and Sertoli cells
• treatment with retinoic acid enhances synchrony of spermatogenesis
• however, by 9 weeks of age, spermatogenesis is similar to controls
• in adults only 1 of 48 males shows spermatogenesis with an altered stage frequency
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• fail to initiate meiosis at 2 and 3 weeks of age
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• numerous degenerated germ cells are present in the testes at 2 and 3 weeks of age
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• males under 7 weeks of age are infertile or subfertile
• however, mice over 9 weeks of age are fertile and produce litters similar in size to controls
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endocrine/exocrine glands
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• most tubules are devoid of meiotic cells at 2 and 3 weeks of age, retaining only undifferentiated spermatogonia-like cells and Sertoli cells
• however, by 9 weeks of age, tubules contain the expected spermatogonia,
spermatocytes, and spermatids
|
|
|
• over 85% of tubules are degenerated at 2 and 3 weeks of age
|
small testis
(
J:193281
)
|
|
• at 2 and 3 weeks of age
|
|
|
• dramatically lower at 2 and 3 weeks of age compared to wild-type controls and homozygous mice carrying only one of the cre transgenes
|
cellular
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• block of differentiation of Aal spermatogonia into A1 spermatogonia at 2 and 3 weeks of age
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• fail to initiate meiosis at 2 and 3 weeks of age
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