Analysis Tools
immune system
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• at 24 hours after diphtheria toxin injection, numbers of PMNs are significantly decreased in bone marrow compared to controls
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• 6 hours after diphtheria toxin injection to induce dendritic cell depletion in noninfected mice, slightly increased polymorphonuclear neutrophil (PMN) cell numbers are detected in the blood, with a 2-fold increase after 24 hours, and peaking at a 5-fold increase at 72 hours after DT treatment; higher intrarenal PMN numbers are seen at 24 and 72 hour
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• with injection of diphtheria toxin (DT) when transurethral instillation of uropathogenic E. coli (UPEC) is performed to produce a model of pyelonephritis, kidney dendritic cell numbers are reduced by 50% by 6 hours after DT treatment; 30 hours after DT-induced dendritic cell depletion, dendritic cell numbers are decreased by more than 90% in kidney
• the remaining dendritic cells are not functional, as they do not produce chemokines to attract polymorphonuclear neutrophils
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• blood monocyte numbers are 2-3 fold greater than control values at 72 hours after DT injection; intrarenal macrophage numbers are increased, peaking at 72 hours after DT
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• with diphtheria toxin injection at time of induction of pyelonephritis by transurethral infection by UPEC, polymorphonuclear neutrophil (PMN) recruitment is decreased
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• after DT injection, an increase in Cxcl2 level is observed in serum, but not in Il1, 4, 5 or 7, Tnf, Ccl2, 3, or 5 levels
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• at 30 hours after dendritic cell depletion in kidney by DT injection and infection with uropathogenic E. coli, numbers of polymorphonuclear neutrophils in kidneys are elevated and a 5-fold decrease in colony forming units of UPEC is observed compared to nondepleted control animals
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• with diphtheria toxin at time of induction of pyelonephritis by transurethral infection by UPEC, animals show impaired bacterial clearance
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hematopoietic system
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• at 24 hours after diphtheria toxin injection, numbers of PMNs are significantly decreased in bone marrow compared to controls
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• 6 hours after diphtheria toxin injection to induce dendritic cell depletion in noninfected mice, slightly increased polymorphonuclear neutrophil (PMN) cell numbers are detected in the blood, with a 2-fold increase after 24 hours, and peaking at a 5-fold increase at 72 hours after DT treatment; higher intrarenal PMN numbers are seen at 24 and 72 hour
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• with injection of diphtheria toxin (DT) when transurethral instillation of uropathogenic E. coli (UPEC) is performed to produce a model of pyelonephritis, kidney dendritic cell numbers are reduced by 50% by 6 hours after DT treatment; 30 hours after DT-induced dendritic cell depletion, dendritic cell numbers are decreased by more than 90% in kidney
• the remaining dendritic cells are not functional, as they do not produce chemokines to attract polymorphonuclear neutrophils
|
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• blood monocyte numbers are 2-3 fold greater than control values at 72 hours after DT injection; intrarenal macrophage numbers are increased, peaking at 72 hours after DT
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• with diphtheria toxin injection at time of induction of pyelonephritis by transurethral infection by UPEC, polymorphonuclear neutrophil (PMN) recruitment is decreased
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homeostasis/metabolism
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• after DT injection, an increase in Cxcl2 level is observed in serum, but not in Il1, 4, 5 or 7, Tnf, Ccl2, 3, or 5 levels
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