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Phenotypes Associated with This Genotype
Genotype
MGI:5476987
Allelic
Composition		 Mutyhtm1Yun/Mutyhtm1Yun
Ogg1tm1Yun/Ogg1tm1Yun
Genetic
Background		 involves: 129S/SvEv * C57BL/6JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mutyhtm1Yun mutation (2 available); any Mutyh mutation (34 available)
Ogg1tm1Yun mutation (1 available); any Ogg1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased susceptibility to neuronal excitotoxicity ( J:193978 )
• 3-NP-treated mice exhibit better motor performance with neither medium spiny neuron loss, microgliosis nor single strand break accumulation compared with Ogg1tm1Skmi homozygotes

cellular
decreased susceptibility to neuronal excitotoxicity ( J:193978 )
• 3-NP-treated mice exhibit better motor performance with neither medium spiny neuron loss, microgliosis nor single strand break accumulation compared with Ogg1tm1Skmi homozygotes

homeostasis/metabolism
decreased susceptibility to neuronal excitotoxicity ( J:193978 )
• 3-NP-treated mice exhibit better motor performance with neither medium spiny neuron loss, microgliosis nor single strand break accumulation compared with Ogg1tm1Skmi homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory