About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5484525
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Exo1tm1Wed/Exo1tm1Wed
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic
Background		 involves: 129 * C57BL/6 * CBA/JNCrlj * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Exo1tm1Wed mutation (0 available); any Exo1 mutation (45 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (47 available)
Trp53bp1tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells

hematopoietic system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory