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Phenotypes Associated with This Genotype
Genotype
MGI:5484559
Allelic
Composition		 Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+
Smn1tm1Hung/Smn1+
Tg(SMN2)2Hung/0
Genetic
Background		 B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir mutation (0 available); any Gt(ROSA)26Sor mutation (1024 available)
Smn1tm1Hung mutation (4 available); any Smn1 mutation (87 available)
Tg(SMN2)2Hung mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal motor neuron morphology ( J:193844 )
• increased motor neuron size compared with Smn1tm1Hung/Smn1+ Tg(SMN2)2Hung mice
abnormal neuromuscular synapse morphology ( J:193844 )
• at P4 and P8, endplate size is increased compared to in Smn1tm1Hung/Smn1+ Tg(SMN2)2Hung mice
• at P1 and P4, endplates exhibit an increase in axon input compared with Smn1tm1Hung/Smn1+ Tg(SMN2)2Hung mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory