Phenotypes Associated with This Genotype

Genotype
MGI:5484566

• Allelic Composition: Hltf^tm1.1Arte/Hltf^tm1.1Arte
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron physiology ( J:193813 )

♂ • absence of the the fluoxetine-induced increase in survival of newborn neurons that is seen in wild-type controls

abnormal neuronal precursor proliferation ( J:193813 )

♂ • absence of the fluoxetine-induced increase in neuronal precursor proliferation that is seen in wild-type controls

behavior/neurological

impaired behavioral response to xenobiotic ( J:193813 )

♂ • fail to show a decrease in latency to feed in response to fluoxetine treatment in a novelty suppressed feeding assay, unlike wild-type controls

cellular

abnormal neuronal precursor proliferation ( J:193813 )

♂ • absence of the fluoxetine-induced increase in neuronal precursor proliferation that is seen in wild-type controls