Phenotypes Associated with This Genotype

Genotype
MGI:5491051

ot20

• Allelic Composition: Mecp2^tm1.1Bird/Y
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:194039 )

♂ • median lifespan of 76 days

growth/size/body

increased body weight ( J:194039 )

♂ • starting at 6 weeks of age and reaching a maximum weight by 8 weeks of age

nervous system

abnormal brain development ( J:194039 )

♂ • brain weight peaks at 7 weeks (1 week earlier than in controls) then declines

decreased brain weight ( J:194039 )

♂ • brain weight peaks at 7 weeks (1 week earlier than in controls) then declines

abnormal hippocampus morphology ( J:194039 )

♂ • decrease in the number of ATRX containing foci at 7 weeks of age and only a few foci are detected at 9 weeks of age

abnormal cerebral cortex morphology ( J:194039 )

♂ • decrease in the number of ATRX containing foci at 7 weeks of age and only a few foci are detected at 9 weeks of age

behavior/neurological

tremors ( J:194039 )

♂ • at all ages tested and severity increases with age

abnormal gait ( J:194039 )

♂ • at all ages tested and severity increases with age

integument

disheveled coat ( J:194039 )

♂ • at 8 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:194039