Phenotypes for Map3k8 Nfkb1 MGI:5491301 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Map3k8^tm1Pnt/Map3k8^tm1Pnt Nfkb1^tm1Sley/Nfkb1^tm1Sley
Genetic Background	involves: 129S1/Sv * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8^tm1Pnt mutation (0 available); any Map3k8 mutation (41 available)
Nfkb1^tm1Sley mutation (0 available); any Nfkb1 mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased circulating interleukin-12b level ( J:196528 )

• after LPS injection

decreased interleukin-12b secretion ( J:196528 )

• in bone marrow-derived macrophage

decreased tumor necrosis factor secretion ( J:196528 )

• from bone marrow-derived macrophage stimulated with LPS

• from primary peritoneal macrophages from mice stimulated with LPS

homeostasis/metabolism

decreased circulating interleukin-12b level ( J:196528 )

• after LPS injection

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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