Phenotypes Associated with This Genotype

Genotype
MGI:5495543

• Allelic Composition: Unc5d^tm1Kln/Unc5d^tm1Kln
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon extension ( J:196042 )

• growth cone collapse response to FLRT2-Fc (constant region fragment; Fc), but not FLRT3-Fc, is impaired compared to in wild-type cortical neurons

abnormal neuronal migration ( J:196042 )

• at E15.5, radial migration of a subpopulation of cortical neurons is accelerated compared to wild-type neurons

behavior/neurological

behavior/neurological phenotype ( J:196042 )

N • mice exhibit normal behavior

cellular

abnormal axon extension ( J:196042 )

• growth cone collapse response to FLRT2-Fc (constant region fragment; Fc), but not FLRT3-Fc, is impaired compared to in wild-type cortical neurons

abnormal neuronal migration ( J:196042 )

• at E15.5, radial migration of a subpopulation of cortical neurons is accelerated compared to wild-type neurons