Phenotypes Associated with This Genotype

Genotype
MGI:5496012

• Allelic Composition: Shh^tm2Amc/Shh^tm2Amc; Tg(Atp4b-cre/ERT2)1Jrgo/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:191241 )

N • total parietal cell number remains unchanged following tamoxifen treatment

abnormal gastric surface mucous cell morphology ( J:191241 )

• at 7 and 60 days after final tamoxifen injection, expansion of surface mucous cells (foveolar hyperplasia) is observed, but at 150 days, surface mucous cell numbers are comparable to controls

abnormal stomach pH ( J:191241 )

• parietal cells do not function in mutants treated with tamoxifen; parietal cells do not secrete acid in response to histamine stimulation

homeostasis/metabolism

delayed wound healing ( J:191241 )

• in an acetic acid ulceration model, healing is delayed relative to controls at 7 days after ulcer induction (ulcer size is decreased in controls); granulation tissue below the ulcer is observed in controls but not in mutants 7 days after induction

• in contrast to control mice, mutants do not exhibit macrophage recruitment to the ulcer site 2 days after ulcer induction; macrophage numbers are increased in stomachs of injured controls, but not in mutants

cardiovascular system

abnormal physiological neovascularization ( J:191241 )

• 7 days after acetic acid injury, control mice display an increase in new microvessels compared to PBS-treated controls, but PBS-treated mutants have significantly fewer CD31-positive microvessels relative to controls with no significant change after acetic acid injury