Phenotypes Associated with This Genotype

Genotype
MGI:5501496

• Allelic Composition: Stat3^tm2Aki/Stat3^tm2Aki; Tg(KRT5-cre)1Tak/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

lacrimal gland inflammation ( J:194832 )

• dacroadenitis

conjunctivitis ( J:194832 )

abnormal eye morphology ( J:194832 )

• periocular disease

immune system

lacrimal gland inflammation ( J:194832 )

• dacroadenitis

conjunctivitis ( J:194832 )

dermatitis ( J:194832 )

• lymphocyte infiltrating periocular dermatitis

integument

decreased keratinocyte migration ( J:65302 )

• keratinocyte migration is impaired

dermatitis ( J:194832 )

• lymphocyte infiltrating periocular dermatitis

abnormal hair follicle morphology ( J:65302 )

• mice exhibit small clustering of matrix cells, which resemble undifferentiated hair germs, distorted or curved hair shafts or gigantic hair bulbs with bizarre shapes

decreased hair follicle number ( J:65302 )

abnormal hair cycle anagen phase ( J:65302 )

• unlike in wild-type mice the second anagen does not occur

hyperkeratosis ( J:65302 )

acanthosis ( J:65302 )

spontaneous skin ulceration ( J:65302 )

• mice exhibit skin ulcerations that worsen with age

skin fibrosis ( J:65302 )

• during the late anagen stage mice exhibit dermal fibrosis with inflammatory infiltrate and atrophic change in adipose tissue

endocrine/exocrine glands

lacrimal gland inflammation ( J:194832 )

• dacroadenitis

cellular

decreased keratinocyte migration ( J:65302 )

• keratinocyte migration is impaired

homeostasis/metabolism

impaired wound healing ( J:65302 )