Phenotypes Associated with This Genotype

Genotype
MGI:5502187

• Allelic Composition: Cxcr4^tm1Tng/Cxcr4^tm2Tng; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

poor arterial differentiation ( J:195048 )

abnormal skin vasculature morphology ( J:195048 )

• mice exhibit a failure of nerve-vessel alignment in developing limb skin compared with wild-type mice

• however, vascular density is normal

abnormal developmental vascular remodeling ( J:195048 )

• disorganized branching patterns in developing limb skin

abnormal vascular smooth muscle morphology ( J:195048 )

• reduced smooth muscle cell coverage of small diameter branched vessels

• however, coverage of large diameter veins is normal

nervous system

nervous system phenotype ( J:195048 )

N • mice exhibit normal innervation accompanied by migrating Schwann cells

integument

abnormal skin vasculature morphology ( J:195048 )

• mice exhibit a failure of nerve-vessel alignment in developing limb skin compared with wild-type mice

• however, vascular density is normal

muscle

abnormal vascular smooth muscle morphology ( J:195048 )

• reduced smooth muscle cell coverage of small diameter branched vessels

• however, coverage of large diameter veins is normal