Phenotypes Associated with This Genotype

Genotype
MGI:5502351

• Allelic Composition: Nabp2^tm1.1Kkha/Nabp2^tm1.1Kkha; Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Testicular degeneration in Nabp2^tm1.1Kkha/Nabp2^tm1.1Kkha Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ mice

mortality/aging

increased mortality induced by ionizing radiation ( J:195140 )

• in tamoxifen-treated mice

reproductive system

reproductive system phenotype ( J:195140 )

♀N • tamoxifen-treated female mice exhibit normal fertility

abnormal male germ cell morphology ( J:195140 )

♂ • premature sloughing from the supporting Sertoli cells in tamoxifen-treated mice

oligozoospermia ( J:195140 )

♂ • due to apoptosis and premature sloughing from the supporting Sertoli cells in tamoxifen-treated mice

♂ • decreased elongated spermatids

abnormal male germ cell apoptosis ( J:195140 )

♂ • in tamoxifen-treated mice

small testis ( J:195140 )

♂ • in tamoxifen-treated mice

decreased testis weight ( J:195140 )

♂ • in tamoxifen-treated mice

testis degeneration ( J:195140 )

♂ • bilateral degeneration; tubules showed degenerate, sometimes vacuolated, or necrotic spermatogenic cells, the latter with pyknotic nuclei and hypereosinophilic cytoplasm, or apoptotic body formation in tamoxifen-treated mice

decreased litter size ( J:195140 )

♂ • from tamoxifen-treated mice with longer intervals between litters

reduced male fertility ( J:195140 )

♂ • in tamoxifen-treated mice

neoplasm

increased tumor incidence ( J:195140 )

• splenic and metastatic B lymphomas, T cell lymphoma in thymus, hepatocellular carcinoma and B or T lymphoblastic leukemia in 11 of 35 of tamoxifen-treated mice

increased T cell derived lymphoma incidence ( J:195140 )

• in thymus of some tamoxifen-treated mice

increased hepatocellular carcinoma incidence ( J:195140 )

• in some tamoxifen-treated mice

increased leukemia incidence ( J:195140 )

• B or T lymphoblastic leukemia in some tamoxifen-treated mice

increased B cell derived lymphoma incidence ( J:195140 )

• splenic and metastatic B lymphomas in some tamoxifen-treated mice

cellular

abnormal male germ cell morphology ( J:195140 )

♂ • premature sloughing from the supporting Sertoli cells in tamoxifen-treated mice

oligozoospermia ( J:195140 )

♂ • due to apoptosis and premature sloughing from the supporting Sertoli cells in tamoxifen-treated mice

♂ • decreased elongated spermatids

increased cellular sensitivity to ionizing radiation ( J:195140 )

• tamoxifen-treated mice exposed to ionizing radiation exhibit distended crypt lumina lined by attenuated enterocytes, desquamated necrotic cellular debris and a small increase of cells near deep crypts with apoptotic bodies

• however, blood counts are normal in irradiated tamoxifen-treated mice

increased thymocyte apoptosis ( J:195140 )

• in irradiated tamoxifen-treated mice

abnormal male germ cell apoptosis ( J:195140 )

♂ • in tamoxifen-treated mice

chromosomal instability ( J:195140 )

• in tamoxifen-treated mice

growth/size/body

decreased body length ( J:195140 )

• at E14.5 and E18.5

digestive/alimentary system

abnormal small intestine morphology ( J:195140 )

• tamoxifen-treated mice exposed to ionizing radiation exhibit distended crypt lumina lined by attenuated enterocytes, desquamated necrotic cellular debris and a small increase of cells near deep crypts with apoptotic bodies

immune system

increased thymocyte apoptosis ( J:195140 )

• in irradiated tamoxifen-treated mice

endocrine/exocrine glands

increased thymocyte apoptosis ( J:195140 )

• in irradiated tamoxifen-treated mice

small testis ( J:195140 )

♂ • in tamoxifen-treated mice

decreased testis weight ( J:195140 )

♂ • in tamoxifen-treated mice

testis degeneration ( J:195140 )

♂ • bilateral degeneration; tubules showed degenerate, sometimes vacuolated, or necrotic spermatogenic cells, the latter with pyknotic nuclei and hypereosinophilic cytoplasm, or apoptotic body formation in tamoxifen-treated mice

increased T cell derived lymphoma incidence ( J:195140 )

• in thymus of some tamoxifen-treated mice

hematopoietic system

hematopoietic system phenotype ( J:195140 )

N • blood counts are normal in irradiated tamoxifen-treated mice

increased thymocyte apoptosis ( J:195140 )

• in irradiated tamoxifen-treated mice

homeostasis/metabolism

increased mortality induced by ionizing radiation ( J:195140 )

• in tamoxifen-treated mice

liver/biliary system

increased hepatocellular carcinoma incidence ( J:195140 )

• in some tamoxifen-treated mice