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Phenotypes Associated with This Genotype
Genotype
MGI:5503225
Allelic
Composition
Nek8tm1Bei/Nek8tm1Bei
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek8tm1Bei mutation (1 available); any Nek8 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes die shortly after birth

growth/size/body
• kidney development is normal through E15.5
• glomerular cysts begin to appear by E16.5
• fewer cysts than in mice with the juvenile cystic kidney mutation
• in about 2/3 of mice displaying right pulmonary isomerism
• left lung with four lobes as seen in the right lung - in about 61% of mice
• in about 24% of mice
• 15% of mice are normal

cardiovascular system
• focal hemorrhage frequently seen at mid gestation

homeostasis/metabolism
• frequently occurs at mid gestation

renal/urinary system
• kidney development is normal through E15.5
• glomerular cysts begin to appear by E16.5
• fewer cysts than in mice with the juvenile cystic kidney mutation
• tubules have thin walls and are slightly dilated at birth
• tubules are not dilated at E18.5

respiratory system
• left lung with four lobes as seen in the right lung - in about 61% of mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory