Phenotypes Associated with This Genotype

Genotype
MGI:5506522

• Allelic Composition: Etv1^tm2Tmj/Etv1^tm2Tmj; Tg(Ntrk3-EGFP)BM45Gsat/0
• Genetic Background: involves: 129S1/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal axon guidance ( J:197913 )

• in P5-6 mutants, almost complete depletion in the laterally-targeted pSN axon fascicle at T9, L2 and L5 spinal cord levels; medially-oriented pSN axons are greatly reduced in number at all segmental levels compared to controls

nervous system

abnormal axon guidance ( J:197913 )

• in P5-6 mutants, almost complete depletion in the laterally-targeted pSN axon fascicle at T9, L2 and L5 spinal cord levels; medially-oriented pSN axons are greatly reduced in number at all segmental levels compared to controls

decreased sensory neuron number ( J:197913 )

• number of proprioceptive sensory neurons (pSNs) detected in DRGs at level of L2 are decreased by 30% at P0 and by P10, there is 80% loss; at L5 levels, pSN number is decreased by 40% at P0 and P10