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Phenotypes Associated with This Genotype
Genotype
MGI:5508904
Allelic
Composition
Tbx18tm2Akis/Tbx18tm2Akis
Genetic
Background
involves: NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx18tm2Akis mutation (0 available); any Tbx18 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• partial bilateral absence of pleuropericardial membranes in the hilus region resulting in unseparated pleural and pericardial cavities
• pleuropericardial membrane development is disturbed in embryos such that at E11.5-E12.5, embryos fail to form the sinuatrial mesenchymal ridges, the pericardioperitoneal canals are broader and the sinus horns are abnormally positioned
• the pleuropericardial membranes are not connected to the sternum and to the hilus of the lungs at E14.5 and E18.5 and are only attached at one point at the lateral body wall
• the pericardioperitoneal canals do not close at E14.5 as in controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory