Phenotypes Associated with This Genotype

Genotype
MGI:5512989

• Allelic Composition: Notch1^tm2Rko/Notch1^tm2Rko; Tg(KRT14-rtTA)F42Efu/0; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

Meibomian gland degeneration ( J:194073 )

• mutants treated with doxycycline from P1 to P16 show degeneration of ocular glands, including lacrimal and Meibomian glands

lacrimal gland degeneration ( J:194073 )

• mutants treated with doxycycline from P1 to P16 show degeneration of ocular glands, including lacrimal and Meibomian glands

decreased conjunctiva goblet cell number ( J:194073 )

• mutants treated with doxycycline from P1 to P16 exhibit loss of conjunctival goblet cells

dry eyes ( J:194073 )

• mutants treated with doxycycline from P1 to P16 have poor tear volume

endocrine/exocrine glands

Meibomian gland degeneration ( J:194073 )

• mutants treated with doxycycline from P1 to P16 show degeneration of ocular glands, including lacrimal and Meibomian glands

lacrimal gland degeneration ( J:194073 )

• mutants treated with doxycycline from P1 to P16 show degeneration of ocular glands, including lacrimal and Meibomian glands

integument

Meibomian gland degeneration ( J:194073 )

• mutants treated with doxycycline from P1 to P16 show degeneration of ocular glands, including lacrimal and Meibomian glands

alopecia ( J:194073 )

• mutants treated with doxycycline from P1 to P16 show hair loss on the skin and eyelids