Phenotypes Associated with This Genotype

Genotype
MGI:5513846

• Allelic Composition: Cnih2^tm1.1Ran/Cnih2^tm1.1Ran
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:197912 )

N • NMDAR-evoked excitatory postsynaptic current amplitude and paired-pulse ratio are normal

abnormal AMPA-mediated synaptic currents ( J:197912 )

• AMPAR deactivation and desensitization in cre-treated neurons are faster than in control mice

reduced AMPA-mediated synaptic currents ( J:197912 )

• reduced AMPAR-evoked excitatory postsynaptic current amplitude with speedier decay in acute mouse slices infected with a cre-expressing adenovirus or slices transfected with cre

• reduced AMPAR somatic extrasynaptic currents in cre-treated neurons

abnormal miniature excitatory postsynaptic currents ( J:197912 )

• reduced amplitude with faster decay in cre-infected neurons