Phenotypes Associated with This Genotype

Genotype
MGI:5514055

• Allelic Composition: Ostm1^om/Ostm1^om
• Genetic Background: C3HeB/FeJ-Ostm1^om

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:195249 )

• however, provision with soft food improves survival

premature death ( J:195249 )

• shortened life span in some mice

skeleton

abnormal incisor morphology ( J:195249 )

• at P14, P21 and P30 to P32, some mice exhibit small or thinner teeth or missing incisors

• most incisors erupt but appear damaged and degenerate within the first month of life

short incisors ( J:195249 )

abnormal molar morphology ( J:195249 )

• molars are not regularly aligned

• upper molar 3 appears damaged

• some molars are still covered with bone and an epithelial cell layer

failure of tooth eruption ( J:195249 )

• most molars fail to erupt

abnormal maxilla morphology ( J:195249 )

• rough appearance around the roots of damaged upper incisors

• sclerosis in the maxillary area

abnormal maxillary zygomatic process morphology ( J:195249 )

• the zygomatic process of the maxilla is thicker and continues to be thick halfway into the zygomatic bone compared to in wild-type mice

abnormal long bone morphology ( J:195249 )

• layered appearance

abnormal deltoid tuberosity morphology ( J:195249 )

• increased density and abnormal morphology

abnormal femur morphology ( J:195249 )

• increased density of the diaphyses in female mice

• increased density at the distal epiphysis

short femur ( J:195249 )

abnormal rib morphology ( J:195249 )

• thick proximal ribs 1 through 8, especially on the dorsal parts

decreased bone mineral density ( J:195249 )

• full body, femur or right knee in female mice at 8 and 12 weeks

• in male mice at 8 but not 12 weeks

abnormal compact bone morphology ( J:195249 )

• in the jaw, the compact bone is invaded by blood vessels and has a very irregular structure

abnormal trabecular bone morphology ( J:195249 )

• disorganized in the jaw

osteopetrosis ( J:195249 )

♀ • progressive in female, but not male, mice

craniofacial

abnormal incisor morphology ( J:195249 )

• at P14, P21 and P30 to P32, some mice exhibit small or thinner teeth or missing incisors

• most incisors erupt but appear damaged and degenerate within the first month of life

short incisors ( J:195249 )

abnormal molar morphology ( J:195249 )

• molars are not regularly aligned

• upper molar 3 appears damaged

• some molars are still covered with bone and an epithelial cell layer

failure of tooth eruption ( J:195249 )

• most molars fail to erupt

abnormal maxilla morphology ( J:195249 )

• rough appearance around the roots of damaged upper incisors

• sclerosis in the maxillary area

abnormal maxillary zygomatic process morphology ( J:195249 )

• the zygomatic process of the maxilla is thicker and continues to be thick halfway into the zygomatic bone compared to in wild-type mice

homeostasis/metabolism

decreased circulating LDL cholesterol level ( J:195249 )

• likely due to poor nutritional status

decreased circulating triglyceride level ( J:195249 )

• likely due to poor nutritional status

increased circulating alkaline phosphatase level ( J:195249 )

• at 16 weeks

growth/size/body

abnormal incisor morphology ( J:195249 )

• at P14, P21 and P30 to P32, some mice exhibit small or thinner teeth or missing incisors

• most incisors erupt but appear damaged and degenerate within the first month of life

short incisors ( J:195249 )

abnormal molar morphology ( J:195249 )

• molars are not regularly aligned

• upper molar 3 appears damaged

• some molars are still covered with bone and an epithelial cell layer

failure of tooth eruption ( J:195249 )

• most molars fail to erupt

decreased lean body mass ( J:195249 )

decreased body size ( J:195249 )

• around time of weaning

adipose tissue

decreased total body fat amount ( J:195249 )

pigmentation

abnormal coat/hair pigmentation ( J:195249 )

• more grey less yellow coat color

hematopoietic system

decreased hemoglobin content ( J:195249 )

• likely due to poor nutritional status

integument

abnormal coat/hair pigmentation ( J:195249 )

• more grey less yellow coat color

limbs/digits/tail

abnormal deltoid tuberosity morphology ( J:195249 )

• increased density and abnormal morphology

abnormal femur morphology ( J:195249 )

• increased density of the diaphyses in female mice

• increased density at the distal epiphysis

short femur ( J:195249 )