Phenotypes Associated with This Genotype

Genotype
MGI:5514138

• Allelic Composition: Mir21a^tm1.1Zqy/Mir21a^tm1.1Zqy; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129S/SvEv * C3H * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decrease in elastin and collagen content in Mir21a^tm1.1Zqy/Mir21a^tm1.1Zqy Tg(Tek-cre)12Flv/0 aorta

cardiovascular system

abnormal aorta collagen fibril morphology ( J:199907 )

• decreased collagen

decreased aorta elastin content ( J:199907 )

abnormal thoracic aorta morphology ( J:199907 )

• increased opening angle, decreased inner diameter, increased wall thickness/inner diameter ratio

• decreased elastin and collagen content and increased aortic stiffness

decreased mean systemic arterial blood pressure ( J:199907 )

decreased systemic arterial diastolic blood pressure ( J:199907 )

abnormal blood vessel physiology ( J:199907 )

• decreased norepinephrine-induced maximal tension in aortic strips

• increased aortic stiffness and decreased compliance of the aorta

decreased vasodilation ( J:199907 )

• decreased sensitivity to acetylcholine induced relaxation

muscle

decreased vasodilation ( J:199907 )

• decreased sensitivity to acetylcholine induced relaxation