Phenotypes Associated with This Genotype

Genotype
MGI:5514233

• Allelic Composition: Ppbp^{tm1(KOMP)Vlcg}/Ppbp^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:198197 )

N • under normal conditions, mice exhibit normal platelet thrombotic response and GR1+ leukocyte rolling or recruitment to thrombi

abnormal leukocyte physiology ( J:198197 )

• following vascular injury, mice exhibit a major reduction in leukocyte shape change and leukocyte migration through thrombi compared with wild-type mice

abnormal leukocyte migration ( J:198197 )

• impaired migration following vascular injury

homeostasis/metabolism

abnormal response to injury ( J:198197 )

• following vascular injury, mice exhibit a major reduction in leukocyte shape change and leukocyte migration through thrombi compared with wild-type mice

cellular

abnormal leukocyte migration ( J:198197 )

• impaired migration following vascular injury

hematopoietic system

abnormal leukocyte physiology ( J:198197 )

• following vascular injury, mice exhibit a major reduction in leukocyte shape change and leukocyte migration through thrombi compared with wild-type mice

abnormal leukocyte migration ( J:198197 )

• impaired migration following vascular injury