Phenotypes Associated with This Genotype

Genotype
MGI:5517706

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(Nkx2-1-cre)2Sand/0
• Genetic Background: B6.Cg-Pten^tm1Hwu Tg(Nkx2-1-cre)2Sand

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thyroid gland morphology ( J:197590 )

• at P14, thyroid architecture is altered, with multilayered epithelial cells surrounding the colloid lumen and with some dysmorphic follicles containing abnormal material inside

abnormal thyroid follicle morphology ( J:197590 )

• dysmorphic follicles containing abnormal material inside and multiple degenerative follicles which have varying degrees of colloid depletion are seen at P14

enlarged thyroid gland ( J:197590 )

• increase in thyroid size is already seen at E15.5 and is striking by P14

thyroid gland hyperplasia ( J:197590 )

• increase in epithelial cell proliferation rate at E15.5 and P14

• Background Sensitivity: at P14, epithelial cell proliferation rates are higher on the congenic C57BL/6 background than on the BALB/c background

increased thyroid adenoma incidence ( J:197590 )

• at P14, thyroid structure is completely altered with multiple degenerative follicles, which have varying degrees of colloid depletion, resembling a follicular adenoma

homeostasis/metabolism

decreased thyroxine level ( J:197590 )

• decrease in T4 hormonal levels at P14

increased thyroid-stimulating hormone level ( J:197590 )

• increase in TSH at P14

mortality/aging

postnatal lethality, complete penetrance ( J:197590 )

• all mutants die before 2 weeks of age due to compression of the trachea and esophagus by the enlarged thyroid

neoplasm

increased thyroid adenoma incidence ( J:197590 )

• at P14, thyroid structure is completely altered with multiple degenerative follicles, which have varying degrees of colloid depletion, resembling a follicular adenoma