Phenotypes Associated with This Genotype

Genotype
MGI:5517709

• Allelic Composition: Pten^tm1Hwu/Pten⁺; Tg(Nkx2-1-cre)2Sand/0
• Genetic Background: B6.Cg-Pten^tm1Hwu Tg(Nkx2-1-cre)2Sand

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thyroid gland morphology ( J:197590 )

• altered thyroid structure with normal areas that include colloid-filled follicles and normal areas with focal hyperplasia, polynuclear cells, small nonencapsulated areas of hypercellularity with solid and/or mircofollicular patterns and internal hemorrhage

increased thyroid tumor incidence ( J:197590 )

• 100% of mutants develop differentiated follicular tumors of the thyroid after about 2 years of age

homeostasis/metabolism

decreased thyroxine level ( J:197590 )

• P14 mutants show a mild decrease of T4 but normal TSH

neoplasm

increased thyroid tumor incidence ( J:197590 )

• 100% of mutants develop differentiated follicular tumors of the thyroid after about 2 years of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
follicular thyroid carcinoma		DOID:3962	OMIM:188470	J:197590