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Phenotypes Associated with This Genotype
Genotype
MGI:5518952
Allelic
Composition
Gata3tm1.1Gan/Gata3tm1.1Gan
Tg(Pax2-cre)1Akg/0
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1.1Gan mutation (0 available); any Gata3 mutation (32 available)
Tg(Pax2-cre)1Akg mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die shortly after birth

hearing/vestibular/ear
• short cochlea with no obvious turns with some degree of bifurcation at the apex region at E13.5
• prosensory domain development, as determined by marker expression, is disrupted
• however, initial cochleovestibular ganglion generation is normal
• disorganized, miniature, short cochlear duct with no obvious turns
• patchy formation of the organ of Corti-like structures, containing sometimes limited supporting cells either lacking or variable numbers of hair cells
• in some organ of Corti-like structures
• in some organ of Corti-like structures
• no obvious turns
• absent horizontal crista
• however, the anterior cristae seems normal

nervous system
• in some organ of Corti-like structures
• in some organ of Corti-like structures
• auditory fibers and projection defects
• however, neural fibers to the utricle and anterior cristae are normal
• loss of spiral ganglion nerves during early development
• however, initial cochleovestibular ganglion generation is normal
• missing inferior vestibular ganglion

cellular
• in the cochlear duct beyond the prosensory region at E12.5 and E13.5
• in the spiral ganglion nerves during early development


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory