Phenotypes for Ticam1 MGI:5520919 MGI Mouse

increased neutrophil cell number ( J:288471 )

• rMA15-SARS-CoV-infected mice show increased recruitment of neutrophils in the lungs at 4 dpi, however by 6 dpi, this is no longer different

increased plasmacytoid dendritic cell number ( J:288471 )

• mice show more plasmacytoid dendritic cells in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV

• however, no differences from wild-type are seen in populations of eosinophils, monocyte-derived dendritic cells or in CD11b+ dendritic cell populations, or lymphocytes after rMA15-SARS-CoV infection

decreased CD8-positive, alpha-beta T cell number ( J:288471 )

• mice show fewer CD8+ T cells in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV

• however, no differences in the number of CD4+ T cells are seen

increased macrophage cell number ( J:288471 )

• mice show more alveolar macrophages in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV

increased Ly6C high monocyte number ( J:288471 )

• mice show more Ly6C high inflammatory monocytes following rMA15-SARS-CoV infection at 4 dpi but not on 6 dpi

decreased Ly6C low monocyte number ( J:288471 )

• mice show similar numbers of Ly6C low monocytes as wild-type mice following rMA15-SARS-CoV infection at 4 dpi but lower numbers at 6 dpi

abnormal chemokine level ( J:288471 )

• levels of chemokines that are chemotactic for neutrophil recruitment (CXCL1, CXCL2, CXCL3) are lower on 2 dpi with rMA15-SARS-CoV but are higher on 4 dpi

increased interferon-beta secretion ( J:288471 )

• rMA15-SARS-CoV-infected mice show increased IFN-beta levels in lung homogenates on 2 and 4 dpi

increased susceptibility to Coronaviridae infection ( J:288471 )

• mice infected intranasally with the mouse-adapted rMA15-SARS-CoV show greater weight loss and continue to lose weight when wild-type mice are recovering, increased viral loads in the lungs and detectable virus at day 6 post-infection when wild-type mice clear the virus

• mice show greater susceptibility to SARS-CoV infection than Tlr3^tm1Flv homozygotes

• rMA15-SARS-CoV-infected mice show more viral antigen in the lungs; more viral antigen is seen in the parenchyma of the lungs but not in the large airways when compared to wild-type mice

• in the large airways, infected cells in the large airways are ciliated airway epithelial cells and are type II pneumocytes in the alveolar spaces

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:288471 )

• rMA15-SARS-CoV-infection leads to lethality

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:288471 )

• rMA15-SARS-CoV-infection leads to lethality

abnormal chemokine level ( J:288471 )

• levels of chemokines that are chemotactic for neutrophil recruitment (CXCL1, CXCL2, CXCL3) are lower on 2 dpi with rMA15-SARS-CoV but are higher on 4 dpi

decreased susceptibility to injury ( J:193668 )

• following induction of necrotizing enterocolitis, mice exhibit preservation of the small intestinal mucosa compared with wild-type mice

lung hemorrhage ( J:288471 )

• rMA15-SARS-CoV-infected mice show severe hemorrhage in the lungs at day 6 post-infection

abnormal respiratory function ( J:288471 )

• rMA15-SARS-CoV-infected mice show higher levels of enhanced and infection-associated airway obstruction

increased airway responsiveness ( J:288471 )

• rMA15-SARS-CoV-infected mice show higher levels of enhanced pause indicating airway hyperresponsiveness

abnormal forced expiratory flow rates ( J:288471 )

• rMA15-SARS-CoV-infected mice show higher midtidal expiratory flow