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Phenotypes Associated with This Genotype
Genotype
MGI:5521297
Allelic
Composition		 Piwil2tm2.1Doca/Piwil2tm2.1Doca
Tg(Stra8-icre)1Reb/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piwil2tm2.1Doca mutation (1 available); any Piwil2 mutation (54 available)
Tg(Stra8-icre)1Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male germ cell apoptosis ( J:199259 )
• especially in meiotic cells

cellular
abnormal cell physiology ( J:199259 )
• round spermatids fail to exhibit L1 transposon silencing unlike wild-type cells
abnormal male germ cell apoptosis ( J:199259 )
• especially in meiotic cells

endocrine/exocrine glands

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory