Phenotypes Associated with This Genotype

Genotype
MGI:5523484

• Allelic Composition: Exo1^tm2Wed/Exo1^tm2Wed
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decreased testis weight in Exo1^tm2Wed/Exo1^tm2Wed males

mortality/aging

premature death ( J:198719 )

reproductive system

reproductive system phenotype ( J:198719 )

♀N • female mice exhibit normal fertility

oligozoospermia ( J:198719 )

♂ • very few spermatogenic cells progress through meiosis II

abnormal male meiosis ( J:198719 )

♂ • very few spermatogenic cells progress through meiosis II

♂ • abnormal metaphase configurations with abnormal spindle structures

abnormal male germ cell apoptosis ( J:198719 )

♂

small testis ( J:198719 )

♂

decreased testis weight ( J:198719 )

♂

neoplasm

increased tumor incidence ( J:198719 )

increased adenoma incidence ( J:198719 )

• less so than in Exo1^tm3.1Wed homozygotes

increased lymphoma incidence ( J:198719 )

• in most mice without an increase in microsatellite instability

increased sarcoma incidence ( J:198719 )

• less so than in Exo1^tm3.1Wed homozygotes

immune system

abnormal class switch recombination ( J:198719 )

• mice treated with LPS or LPS and IL4 fail to exhibit efficient class switch recombination from IgM to IgG3 or IgG1 compared with wild-type mice

abnormal somatic hypermutation frequency ( J:198719 )

• splenic B cells from mice immunized with NP-CGG exhibit a decrease in the frequency of mutations at the A:T base pairs in Polh hotspots and a bias towards transition mutations at G:C base pairs compared with wild-type B cells

• however, the overall frequency of mutation is normal

cellular

oligozoospermia ( J:198719 )

♂ • very few spermatogenic cells progress through meiosis II

abnormal male meiosis ( J:198719 )

♂ • very few spermatogenic cells progress through meiosis II

♂ • abnormal metaphase configurations with abnormal spindle structures

abnormal male germ cell apoptosis ( J:198719 )

♂

abnormal double-strand DNA break repair ( J:198719 )

• mouse embryonic fibroblasts exhibit impaired double strand break repair through DNA end resection compared with wild-type cells

abnormal mismatch repair ( J:198719 )

• increased mutation frequencies and an increase in transversions

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:198719 )

• mouse embryonic fibroblasts exhibit impaired double strand break repair through DNA end resection compared with wild-type cells

abnormal mismatch repair ( J:198719 )

• increased mutation frequencies and an increase in transversions

endocrine/exocrine glands

small testis ( J:198719 )

♂

decreased testis weight ( J:198719 )

♂

hematopoietic system

abnormal class switch recombination ( J:198719 )

• mice treated with LPS or LPS and IL4 fail to exhibit efficient class switch recombination from IgM to IgG3 or IgG1 compared with wild-type mice

abnormal somatic hypermutation frequency ( J:198719 )

• splenic B cells from mice immunized with NP-CGG exhibit a decrease in the frequency of mutations at the A:T base pairs in Polh hotspots and a bias towards transition mutations at G:C base pairs compared with wild-type B cells

• however, the overall frequency of mutation is normal