Phenotypes for Exo1 Trp53 MGI:5523487 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Exo1^tm3.1Wed/Exo1^tm3.1Wed Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Exo1^tm3.1Wed mutation (0 available); any Exo1 mutation (46 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (244 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:198719 )

• survival is similar to in Trp53^tm1Tyj homozygotes

neoplasm

increased lymphoma incidence ( J:198719 )

• but less than in Trp53^tm1Tyj homozygotes

increased sarcoma incidence ( J:198719 )

• compared with Trp53^tm1Tyj homozygotes

cellular

abnormal chromosome stability ( J:198719 )

• mice exhibit the same amount of segmental chromosomal instability as in Trp53^tm1Tyj homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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