Phenotypes Associated with This Genotype

Genotype
MGI:5523592

• Allelic Composition: Pkdcc^tm1.2Azun/Pkdcc^tm1.2Azun
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:199462 )

digestive/alimentary system

cleft secondary palate ( J:199462 )

respiratory system

respiratory failure ( J:199462 )

skeleton

decreased length of long bones ( J:199462 )

• shorter ossified section at birth

short humerus ( J:199462 )

• tibia and humerus are most severely affected

short tibia ( J:199462 )

• tibia and humerus are most severely affected

abnormal cartilage development ( J:199462 )

• chondrocyte maturation is delayed by at least 2 days with columnar chondrocytes first detected in long bone rudiments at E15.5 instead of E13.5 as in controls

delayed endochondral bone ossification ( J:199462 )

• in long bones

• primary ossification centers have not yet formed at E16.5 in the humerus

growth/size/body

cleft secondary palate ( J:199462 )

decreased birth body size ( J:199462 )

• appear smaller than littermates

craniofacial

cleft secondary palate ( J:199462 )

limbs/digits/tail

short humerus ( J:199462 )

• tibia and humerus are most severely affected

short tibia ( J:199462 )

• tibia and humerus are most severely affected