Analysis Tools
skeleton
|
• the primordia of the tibia and fibula are ectromelic at E16.5
|
absent tibia
(
J:199462
)
|
• the primordia of the tibia and fibula are ectromelic at E16.5
|
|
• deformed in some mice at E16.5
|
|
• at E16.5 few or no columnar and hypertrophic chondrocytes are detected in the limbs
• hypertrophic differentiation is delayed
• expression analysis indicates the number of pre-hypertrophic chondrocytes is severely reduced in the limbs at E15.5 and E16.5
|
|
• at E16.5 no signs of ossification are seen in the humerus, tibia, fibula or digits and mineralization domains in other long bones are reduced
• delay is more severe than in mice homozygous for Pkdcctm1.2Azun alone
|
limbs/digits/tail
polydactyly
(
J:199462
)
|
• the primordia of the tibia and fibula are ectromelic at E16.5
|
absent tibia
(
J:199462
)
|
• the primordia of the tibia and fibula are ectromelic at E16.5
|
