About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5523681
Allelic
Composition		 Notch1tm6.1Rko/Notch1+
Notch2tm3Grid/Notch2tm3Grid
Tg(Pax3-cre)1Joe/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm6.1Rko mutation (0 available); any Notch1 mutation (115 available)
Notch2tm3Grid mutation (2 available); any Notch2 mutation (97 available)
Tg(Pax3-cre)1Joe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal hypoplasia ( J:198632 )
• newborns have hypoplastic kidneys without functional nephrons; one copy of the N2ICD expressed from the Notch1 locus cannot rescue nephrons

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory