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Phenotypes Associated with This Genotype
Genotype
MGI:5524024
Allelic
Composition		 Mdm2tm1Glo/Mdm2+
Trp53tm1.1Tldo/Trp53+
Genetic
Background		 involves: 129S2/SvPas * 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Trp53tm1.1Tldo mutation (0 available); any Trp53 mutation (244 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:199308 )
• some die within 3 months

hematopoietic system
decreased bone marrow cell number ( J:199308 )
• decreased compared to Trp53tm1.1Tldo/+ mice

cellular
decreased telomere length ( J:199308 )
• decreased compared to Trp53tm1.1Tldo/+ mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory