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Phenotypes Associated with This Genotype
Genotype
MGI:5525140
Allelic
Composition		 Egln1tm2.1Fsl/Egln1tm2.1Fsl
Pax3tm1(cre)Joe/Pax3+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm2.1Fsl mutation (0 available); any Egln1 mutation (21 available)
Pax3tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal liver vasculature morphology ( J:202737 )
• number and size of vessels is increased as compared to controls
increased heart weight ( J:202737 )
• increased cardiac mass as compared to controls

hematopoietic system
polycythemia ( J:202737 )
• mice exhibit erythrocytosis, however, erythropoietin levels are not increased
increased hematocrit ( J:202737 )
• mice exhibit hematocrits of over 80%

immune system

liver/biliary system
abnormal liver vasculature morphology ( J:202737 )
• number and size of vessels is increased as compared to controls

growth/size/body
increased heart weight ( J:202737 )
• increased cardiac mass as compared to controls
increased liver weight ( J:202737 )
increased spleen weight ( J:202737 )

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory