Phenotypes Associated with This Genotype

Genotype
MGI:5525153

• Allelic Composition: Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:201572 )

• hematopoietic stem and progenitor cell populations are distorted

decreased common myeloid progenitor cell number ( J:201572 )

• 30 fold decrease in numbers of myeloid progenitors (Sca-1- cKit+, LS-K+)

decreased bone marrow cell number ( J:201572 )

• found in femur and tibia of 5 day old mice as compared to control

decreased erythrocyte cell number ( J:201572 )

• found in peripheral blood of 5 day old mice as compared to control

thrombocytopenia ( J:201572 )

• found in peripheral blood of 5 day old mice as compared to control

decreased leukocyte cell number ( J:201572 )

• found in peripheral blood of 5 day old mice as compared to control

decreased hematopoietic stem cell number ( J:201572 )

• 30 fold decrease in numbers of hematopoietic stem cells and multipotent progenitors (Sca-1+ cKit+, LS+K+)

immune system

decreased leukocyte cell number ( J:201572 )

• found in peripheral blood of 5 day old mice as compared to control

growth/size/body

decreased body size ( J:201572 )

• newborn pups are smaller than controls

mortality/aging

postnatal lethality, incomplete penetrance ( J:201572 )

• lethality is a result severe anemia

• most mice die by day 10