Phenotypes for Cd22 MGI:5526061 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd22^tm2Lnit/Cd22^tm2Lnit
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22^tm2Lnit mutation (0 available); any Cd22 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:198790 )

N	• early B cell development in bone marrow is normal

absent mature B cells ( J:198790 )

• lack of mature recirculating B cells in bone marrow

• reduced in number

autoimmune response ( J:198790 )

• increased Calcium ion response to anti-IgM

hematopoietic system

absent mature B cells ( J:198790 )

• lack of mature recirculating B cells in bone marrow

• reduced in number

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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