Phenotypes Associated with This Genotype

Genotype
MGI:5529263

• Allelic Composition: Apc^Min/Apc⁺; Pla2g2a^Mom1-r/Pla2g2a⁺
• Genetic Background: either: (AKR/J x C57BL/6J-Apc^Min)F1 or (MA/MyJ x C57BL/6J-Apc^Min)F1 or (CAST/EiJ x C57BL/6J-Apc^Min)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased alimentary system tumor incidence ( J:15703 )

• controlled for age of the mice, the mean tumor incidence was 5.8 +/- 4.3 compared with 28.5 +/-7.9 in mice with a C57BL/6J background

• mice homozygous for Pla2g2a^Mom1-r from AKR/J produced by backcrossing the F1 to AKR/J produced offspring with a lower mean tumor incidence of 1.7 +/- 1.7

• mice heterozygous for Pla2g2a^Mom1-r from C57BL/6J and AKR/J produced by backcrossing the F1 to C57BL/6J show a mean tumor incidence significantly lower than seen in mice having a C57BL/6J background but significantly higher than mice homozygous for Pla2g2a from AKR/J

• inbred srains MA/MyJ and CAST/Ei also carry the tumor suppressing allele Pla2g2a^Mom1-r s

decreased intestinal adenoma incidence ( J:15703 )

• inbred strains AKR/J, MA/MyJ, and CAST/Ei are homozygous for the tumor suppressing allele Pla2g2a

digestive/alimentary system

decreased alimentary system tumor incidence ( J:15703 )

• controlled for age of the mice, the mean tumor incidence was 5.8 +/- 4.3 compared with 28.5 +/-7.9 in mice with a C57BL/6J background

• mice homozygous for Pla2g2a^Mom1-r from AKR/J produced by backcrossing the F1 to AKR/J produced offspring with a lower mean tumor incidence of 1.7 +/- 1.7

• mice heterozygous for Pla2g2a^Mom1-r from C57BL/6J and AKR/J produced by backcrossing the F1 to C57BL/6J show a mean tumor incidence significantly lower than seen in mice having a C57BL/6J background but significantly higher than mice homozygous for Pla2g2a from AKR/J

• inbred srains MA/MyJ and CAST/Ei also carry the tumor suppressing allele Pla2g2a^Mom1-r s

decreased intestinal adenoma incidence ( J:15703 )

• inbred strains AKR/J, MA/MyJ, and CAST/Ei are homozygous for the tumor suppressing allele Pla2g2a