Phenotypes Associated with This Genotype

Genotype
MGI:5532317

• Allelic Composition: Hltf^tm1.2Geno/Hltf^tm1.2Geno
• Genetic Background: B6.129S2-Hltf^tm1.2Geno

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Widespread vacuolation in the anteriorcommissure, preoptic/ventral palladium, and motor cortex of Hltf^tm1.2Geno/Hltf^tm1.2Geno neonatal brains

mortality/aging

neonatal lethality, incomplete penetrance ( J:203735 )

• of most mice

nervous system

increased brain apoptosis ( J:203735 )

brain vacuoles ( J:203735 )

• widespread vacuolation in the anterior commissure, preoptic/ventral palladium, and motor cortex

spongiform encephalopathy ( J:203735 )

• widespread and bilateral with increased apoptosis

homeostasis/metabolism

hypoglycemia ( J:203735 )

• in 2 of 3 mice after birth

cellular

increased brain apoptosis ( J:203735 )

behavior/neurological

behavior/neurological phenotype ( J:203735 )

N • mice exhibit normal suckling