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Phenotypes Associated with This Genotype
Genotype
MGI:5532486
Allelic
Composition		 Cysltr1tm1Ykn/Cysltr1tm1Ykn
Cysltr2tm1Ykn/Cysltr2tm1Ykn
Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg
Genetic
Background		 involves: BALB/c * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cysltr1tm1Ykn mutation (2 available); any Cysltr1 mutation (11 available)
Cysltr2tm1Ykn mutation (2 available); any Cysltr2 mutation (34 available)
Oxgr1tm1(KOMP)Vlcg mutation (1 available); any Oxgr1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:198383 )
• at high doses, mice exhibit reduced leukotriene E4 ligand (LTE4) or leukotriene C4 ligand (LTC4)-induced ear edema compared with wild-type mice
• at low and intermediate doses, mice fail to exhibit leukotriene E4 ligand (LTE4)-, leukotriene C4 ligand (LTC4)- or leukotriene D4 (LTD4)-induced ear edema unlike wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory