Phenotypes for H2-Ab1 MGI:5543896 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	H2-Ab1^b-tm1Wug/H2-Ab1^b-tm1Wug
Genetic Background	involves: C57BL/6

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1^b-tm1Wug mutation (1 available); any H2-Ab1 mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:204951 )

• B cells fail to prime MOG-specific 2D2 TCR transgenic CD4 T cell proliferation unlike wild-type cells

• bone marrow-derived dendritic cells fail to generate an antigen-specific response unlike wild-type cells

• resistant in a passive or active model

hematopoietic system

abnormal B cell physiology ( J:204951 )

• B cells fail to prime MOG-specific 2D2 TCR transgenic CD4 T cell proliferation unlike wild-type cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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