Phenotypes Associated with This Genotype

Genotype
MGI:5544572

• Allelic Composition: Wnk1^tm2.1Juha/Wnk1⁺; Tg(Pgk1-cre)1Lni/0
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased distal convoluted tubule fractional volume in Wnk1^tm2.1Juha/Wnk1⁺ Tg(Pgk1-cre)1Lni/0 mice

renal/urinary system

increased urine aldosterone level ( J:200742 )

• elevated 24h urinary aldosterone level

increased urine calcium level ( J:200742 )

• greatly amplified when mice are fed a high Na+ diet

abnormal distal convoluted tubule morphology ( J:200742 )

• increased fractional volume

abnormal kidney physiology ( J:200742 )

• fail to increase K+ and H+ secretion in response to hyperkalemic acidosis

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:200742 )

N • treatment with hydrochlorothiazide for 3d normalizes the metabolic disorders

hyperkalemia ( J:200742 )

increased urine aldosterone level ( J:200742 )

• elevated 24h urinary aldosterone level

increased urine calcium level ( J:200742 )

• greatly amplified when mice are fed a high Na+ diet

increased circulating chloride level ( J:200742 )

• hyperchloremic metabolic acidosis

metabolic acidosis ( J:200742 )

• hyperchloremic metabolic acidosis

hematopoietic system

decreased hematocrit ( J:200742 )

cardiovascular system

increased systemic arterial systolic blood pressure ( J:200742 )

• on a normal diet

• an additional transient increase is seen when mice are switched from a normal (0.3% Na+) to a high (3% Na+) salt diet

• treatment with hydrochlorothiazide for 3d normalizes the blood pressure