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Phenotypes Associated with This Genotype
Genotype
MGI:5546333
Allelic
Composition		 Gdf11tm1Sjl/Gdf11tm1Sjl
Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf11tm1Sjl mutation (0 available); any Gdf11 mutation (14 available)
Wfikkn2tm1.1Sjl mutation (0 available); any Wfikkn2 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Craniofacial defects in Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl Gdf11tm1Sjl/Gdf11tm1Sjl mice

skeleton
abnormal axial skeleton morphology ( J:201148 )
• anteriorly directed homeotic transformation
abnormal sternocostal joint morphology ( J:201148 )
• have 10 or 11 attached ribs
increased rib number ( J:201148 )
• have 10 or 11 attached ribs
increased thoracic vertebrae number ( J:201148 )
• most have 18 thoracic vertebrae
abnormal cervical vertebrae morphology ( J:201148 )
• rarely the anterior tuberculum is on C7
increased lumbar vertebrae number ( J:201148 )
• have 8, 8/9 or 9 lumbar vertebrae

craniofacial
cleft palate ( J:201148 )
• in all mice

digestive/alimentary system
cleft palate ( J:201148 )
• in all mice

growth/size/body
cleft palate ( J:201148 )
• in all mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory