About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5546610
Allelic
Composition
Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic
Background
involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nedd4ltm1Shkr mutation (0 available); any Nedd4l mutation (75 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice that survive beyond birth die by P22
• few mice survive beyond birth

respiratory system
N
• mice exhibit normal surfactant and mucous
• with increased neutrophils as early as P14 in mice that survive to P22
• necrosis of alveolar epithelium in mice that survive to P22
• collapsed alveolar space at E18.5
• in most mice delivered by caesarian section

homeostasis/metabolism
• in most mice delivered by caesarian section

immune system
• in the lungs of mice that survive to P22
• with increased neutrophils as early as P14 in mice that survive to P22

hematopoietic system
• in the lungs of mice that survive to P22


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/17/2024
MGI 6.24
The Jackson Laboratory