Phenotypes Associated with This Genotype

Genotype
MGI:5550539

• Allelic Composition: Becn2^tm1.1Blev/Becn2⁺
• Genetic Background: B6.Cg-Becn2^tm1.1Blev

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired autophagy ( J:203842 )

• impaired basal and starvation-induced autophagy in mouse embryonic fibroblasts

increased susceptibility to diet-induced obesity ( J:203842 )

• when fed a high fat diet

increased circulating glucose level ( J:203842 )

• in a glucose or insulin tolerance test whether fed a regular or high fat diet

impaired glucose tolerance ( J:203842 )

• when fed a regular or high fat diet

• however, rimonabant treatment decreases glucose intolerance

insulin resistance ( J:203842 )

• when fed a regular or high fat diet

growth/size/body

increased body weight ( J:203842 )

• when fed a regular or high fat diet

increased susceptibility to diet-induced obesity ( J:203842 )

• when fed a high fat diet

behavior/neurological

increased food intake ( J:203842 )

• when fed a regular or high fat diet

cellular

impaired autophagy ( J:203842 )

• impaired basal and starvation-induced autophagy in mouse embryonic fibroblasts