Phenotypes Associated with This Genotype

Genotype
MGI:5551716

• Allelic Composition: Klf5^tm1.1Jtd/Klf5⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal prostate morphology in Klf5^tm1.1Jtd/Klf5⁺ Tg(Pbsn-cre)4Prb/0 and Klf5^tm1.1Jtd/Klf5^tm1.1Jtd Tg(Pbsn-cre)4Prb/0 males

reproductive system

abnormal prostate gland anterior lobe morphology ( J:206639 )

• thick cell layers

abnormal prostate gland dorsolateral lobe morphology ( J:206639 )

• thick cell layers

decreased prostate gland weight ( J:206639 )

• increased castration-induced shrinkage of the prostate

• however, administration of androgen restores weight

prostate gland hyperplasia ( J:206639 )

• more severe than in Klf5^tm1.1Jtd/Klf5^tm1.1Jtd Tg(Pbsn-cre)4Prb mice

abnormal prostate gland physiology ( J:206639 )

• increased cell proliferation compared to in Klf5^tm1.1Jtd/Klf5^tm1.1Jtd Tg(Pbsn-cre)4Prb mice and mice with wild-type alleles

neoplasm

neoplasm ( J:206639 )

N • at 1 and 2 years, mice do not develop increased incidence of prostatic intraepithelial neoplasia

endocrine/exocrine glands

abnormal prostate gland anterior lobe morphology ( J:206639 )

• thick cell layers

abnormal prostate gland dorsolateral lobe morphology ( J:206639 )

• thick cell layers

decreased prostate gland weight ( J:206639 )

• increased castration-induced shrinkage of the prostate

• however, administration of androgen restores weight

prostate gland hyperplasia ( J:206639 )

• more severe than in Klf5^tm1.1Jtd/Klf5^tm1.1Jtd Tg(Pbsn-cre)4Prb mice

abnormal prostate gland physiology ( J:206639 )

• increased cell proliferation compared to in Klf5^tm1.1Jtd/Klf5^tm1.1Jtd Tg(Pbsn-cre)4Prb mice and mice with wild-type alleles