Phenotypes Associated with This Genotype

Genotype
MGI:5552737

• Allelic Composition: Ccr2^{tm1.1(CCR2)Rodb}/Ccr2^{tm1.1(CCR2)Rodb}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:203000 )

• CCX140-B treatment improves insulin sensitivity, reduced fasting glucose levels and reduced fasting insulin levels observed in mice fed a high fat diet

abnormal urine protein level ( J:203000 )

• CCX140-B treatment improves albuminuria observed in mice fed a high fat diet

increased physiological sensitivity to xenobiotic ( J:203000 )

• CCX140-B treatment inhibits expression of the human sequence and CCL2-mediated calcium mobilization; improves albuminuria, insulin sensitivity, glomerular hypertrophy and podocyte density diminution; reduced fasting glucose levels, fasting insulin levels and inflammatory macrophages in epididymal fat pads observed in mice fed a high fat diet

• however, CCX140-B treatment does not alter weight gain observed in mice fed a high fat diet

renal/urinary system

abnormal urine protein level ( J:203000 )

• CCX140-B treatment improves albuminuria observed in mice fed a high fat diet

abnormal podocyte morphology ( J:203000 )

• CCX140-B treatment glomerular hypertrophy and podocyte density diminution observed in mice fed a high fat diet

abnormal renal glomerulus morphology ( J:203000 )

• CCX140-B treatment glomerular hypertrophy and podocyte density diminution observed in mice fed a high fat diet

immune system

immune system phenotype ( J:203000 )

N • mice exhibit normal numbers of peripheral blood monocytes and leukocyte chemotaxis

abnormal macrophage morphology ( J:203000 )

• CCX140-B treatment improves inflammatory macrophages in epididymal fat pads observed in mice fed a high fat diet

hematopoietic system

abnormal macrophage morphology ( J:203000 )

• CCX140-B treatment improves inflammatory macrophages in epididymal fat pads observed in mice fed a high fat diet