Phenotypes Associated with This Genotype

Genotype
MGI:5553272

• Allelic Composition: Ercc1^tm2Jhjh/Ercc1^tm2Jhjh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased common myeloid progenitor cell number ( J:206925 )

• at 3, 10 and 20 weeks

• decreased colony forming unit-granulocyte (CFU-G) and granulocyte-macrophage (CFU-GM) at 3, 10 and 20 weeks

decreased granulocyte monocyte progenitor cell number ( J:206925 )

• at 10 and 20 weeks

decreased erythroid progenitor cell number ( J:206925 )

• CFU-B at 3 weeks

decreased hematopoietic stem cell number ( J:206925 )

• decreased total LSK+ cells with a 3-fold decrease in the fraction of multipotent progenitors and an increase in the fraction of long term hematopoietic stem cells at 3 weeks; increase in long term and short term HSCs but decreased in MPP at 10 weeks; increased fraction of short term HSCs but a decrease in MPP at 20 weeks

decreased megakaryocyte-erythroid progenitor cell number ( J:206925 )

• at 10 and 20 weeks

liver/biliary system

abnormal hepatocyte morphology ( J:206925 )

• cells with enlarged nuclei in the liver

growth/size/body

decreased body weight ( J:206925 )

• at 3, 10 and 20 weeks of age