Phenotypes Associated with This Genotype

Genotype
MGI:5554195

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-MAPT*K280*I277P*I308P,-luc)#Eman/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:131379 , J:169532 )

N • tau aggregates, neurofibrillary tangles, and neuron degeneration are not seen even after 22 months after doxycycline removal to induce gene expression (J:131379)

N (J:169532)

impaired synaptic plasticity ( J:169532 )

• decrease in synaptic facilitation in mice at 10 months after doxycycline removal which is reversed upon doxycycline treatment to switch off expression

• mice at 10 months after doxycycline removal show reduced extent of frequency facilitation

decreased post-tetanic potentiation ( J:169532 )

• posttetanic potentiation (PTP) is reduced in CA3 areas of the hippocampus in mice at 10 months after doxycycline removal, however LTP is normal

abnormal paired-pulse facilitation ( J:169532 )

• paired-pulse facilitation (PPF) is altered at the 10 and 20 ms interval in CA1 region of the hippocampus